The World Health Organisation expects the Zika virus, which is spreading through the Americas, to affect between 3 million and 4 million people, a disease expert says.
The WHO's director-general said the spread of the mosquito-borne disease had gone from a mild threat to one of alarming proportions.
Marcos Espinal, an infectious disease expert at the WHO's Americas regional office, said: "We can expect 3 to 4 million cases of Zika virus disease", but he gave no time frame.
There is no vaccine or treatment for Zika, which is a close cousin of dengue and chikungunya and causes mild fever, rash and red eyes.
An estimated 80 per cent of people infected have no symptoms, making it difficult to know whether they have been infected.
WHO Director-General Margaret Chan said the organisation will convene an emergency committee on Monday to help determine the level of the international response to an outbreak of the virus spreading from Brazil that is believed to be linked to severe birth defects.
"The level of alarm is extremely high," Ms Chan told WHO executive board members at a meeting in Geneva.Brazil's Health Ministry said in November 2015 that Zika was linked to a foetal deformation known as microcephaly, in which infants are born with abnormally small heads
"[Zika] is now spreading explosively," she added.
"As of today, cases have been reported in 23 countries and territories in the (Americas) region."
Brazil has reported 3,893 suspected cases of microcephaly, the WHO said last week, more than 30 times more than in any year since 2010 and equivalent to 1 to 2 percent of all newborns in the state of Pernambuco, one of the worst-hit areas.
Ms Chan said that while a direct causal relationship between Zika virus infection and birth malformations has not yet been established, it is "strongly suspected"."The possible links, only recently suspected, have rapidly changed the risk profile of Zika from a mild threat to one of alarming proportions," she said
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