On Saturday evening - just as Passover draws to a close - an eery blood colour will engulf the moon.
It is the third of four successive total 'blood-red' lunar eclipses, each followed by six full moons - an extremely rare 'Tetrad'.
Experts are predicting that the moon will be fully-obscured for five full minutes - and that the rare phenomenon will be visible across North America, Asia and Australia.
According to NASA the incredible alignment has only happened a handful of times in the last two thousand years.
The King James Bible predicts: "The sun shall be turned into darkness, and the moon into blood, before the great and the terrible day of the LORD comes," [Joel 2:31].
The BloodMoon will be visible across North America John Hagee, an American pastor, claims the strange timing of the event - between the anniversary of Jesus's death on Good Friday and His resurrection on Easter Sunday - proves a religiously significant global event is about to unfold.
He said: "There's a sense in the world that things are changing and God is trying to communicate with us in a supernatural way.
"I believe we're going to see something dramatic happen in the Middle East involving Israel that will change the course of history in the Middle East and impact the whole world.”
He added: "What is so remarkable about this blood moon is that it specifically fulfills prophecies set out in the Bible.
"Joel Chapter Two also says the 'Day of the Lord will be as when the sun refuses to shine'.
"Even Jesus himself, in the Book of Luke, states there 'will be signs in the sun, moon and stars' and to 'lift up your heads for redemption draws nigh'.
"There's a sequence of prophetic events that the Bible says will happen. It does not, ever, give a timeline.
"It just says 'when you see these signs' - and four blood moons is a very significant one - 'the end of this age is coming."
The reddish colour seen during a total lunar eclipse is a reflection of light from all the sunsets and sunrises across the world at that time and some experts think this weekend's eclipse will be less overwhelming.
Astronomer Andrew Smith said: “Because the moon’s only skirting just inside the edge of the shadow, it might not be quite as deep an effect.
The total lunar eclipse, unlike a solar eclipse, is completely safe and can be viewed without any protective eyewear.
The Lyrids Meteor Shower will see 20 meteors per hour at its peak on April 21 and 22.
And on May 23, Saturn will be 'at opposition', when the ringed planet will be at its closest point to earth and its face will be fully illuminated by the sun.
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